They say they are a +40. So they have about 5 inches of backspacing. You'd need to run a spacer to run them on a 2wd S10, a 2 inch spacer would put you at about a stock trackwidth. Also, technically a 5 on 4.75 (like S-10's are) isn't the same as a 5 on 120 (like those wheels are). It's very close, and many people do run them that way.