You might have better luck looking at the suspensions forum...........you also have to define "best".........if by best you mean cheapest, go with 3 inch coils and blocks........if you mean '"best" as in ride quality and handling........go with 2 inch spindles a 1-2 inch coil and 3 inch leafs with a 1 inch block
ive got 2" spindles and 1" springs up front and 4 inch blocks in back. the only thing different about the ride was the back end bottoming out over some bumps. what i did to fix that was buy some air shocks (gabriels on Ebay) and run with about 45 to 50 psi and it rides so much better, its amazing.
i'd recommend belltech, they are a reputable company for s10 drop components. the suspension forum may help you better on a question like this too.
Go with spindles and springs in the front. Get a 3" spring for the rear with a 1" block. Any larger size of block will seriously reduce your ride quality. Make sure you get the proper drop shocks as well.