My 2000 must have gotten the left overs for wiring. I bought it brand new off the lot so it is all orginal (or was before this weekend). 4 awg ground to the block, 12 awg to the frame and radiator support (three wires total). On the + side I have 4 awg from the alternator to the distribution block, 6 awg from the disti block to the main fuse block and 6 awg to the battery.
Anyway, just adding the 4 awg ground to the frame raised my volt reading by more than 1/2 a volt in the cab. I don't have a lot of power going through the stereo, but since my sub amp is grounded to the frame it should have a little easier time pushing the sub. I moved the 12 awg wire from the frame to the chassis since it was extra.
I think the ground to frame, and power to the fuse block are probably the weakest links.